٧٫٦٤ % | Avidity Partners Management LP | ٦٬٥٠٠٬٣٢٨ | -٣٢٤٬١٢٢ | ٣١/١٢/٢٠٢٣ |
٧٫٥٣ % | Deerfield Management Company, L.P. | ٦٬٤٠١٬٠٠٠ | ٣٬٥٧٨٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٦٫٢٥ % | Fidelity Management & Research Company LLC | ٥٬٣١٢٬٢٩٧ | ١٬١٣٥٬٤٤٦ | ٣١/١٢/٢٠٢٣ |
٥٫٥٧ % | Perceptive Advisors LLC | ٤٬٧٣٧٬١٩٤ | ١٬٩٨٥٬٧٩٩ | ٩/١/٢٠٢٤ |
٤٫٥٢ % | HealthCap AB | ٣٬٨٤٠٬٧٠٢ | ٣٣٬٤٥٥ | ١٨/٣/٢٠٢٤ |
٤٫٣٢ % | Johnson & Johnson Innovation-JJDC, Inc. | ٣٬٦٧٠٬٥١٦ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫٨٣ % | Varian Medical Systems, Inc. | ٣٬٢٥٦٬٩٧٢ | ٣٬٢٥٦٬٩٧٢ | ١٧/٢/٢٠٢٣ |
٣٫٦٧ % | OrbiMed Advisors, LLC | ٣٬١٢٢٬٧٧٠ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫٦٦ % | CPP Investment Board | ٣٬١١٦٬٩٦٦ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫٤٧ % | Adams Street Partners, LLC | ٢٬٩٤٧٬٨٠٩ | 0 | ٣١/١٢/٢٠٢٣ |
٣٫٠٠ % | TPG Capital, L.P. | ٢٬٥٥١٬٧٩٤ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٨٤ % | Pivotal Bioventure Partners Investment Advisor LLC | ١٬٥٦٠٬٩٨٢ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٢٨ % | Sphera Funds Management Ltd. | ١٬٠٨٥٬٦٣٩ | -٢٦٨٬٦١٩ | ٣١/١٢/٢٠٢٣ |
١٫١٨ % | Invus Public Equities Advisors, LLC | ١٬٠٠٥٬٥٠٠ | -٧١٩٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
١٫١٧ % | William Blair & Company, L.L.C. (Research) | ٩٩٣٬٨٥٥ | ٩٩٣٬٨٥٥ | ٣١/١٢/٢٠٢٣ |
١٢٫٧٧ % | Federated Hermes Global Investment Management Corp. | ١٠٬٨٦٦٬١٥٣ | ٢٨٢٬٣٦٤ | ٣١/١٢/٢٠٢٣ |
٠٫٨٨ % | Wellington Management Company, LLP | ٧٤٤٬٤٧٤ | ٥٧٩٬٩٤٩ | ٣١/١٢/٢٠٢٣ |
٠٫٨٦ % | 1832 Asset Management L.P. | ٧٣٤٬٣٢١ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٦٨ % | Eagle Health Investments LP | ٥٧٩٬٧٦٩ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٦٨ % | Millennium Management LLC | ٥٧٨٬١٠٢ | -٤٬٠٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫٥٩ % | Ikarian Capital LLC | ٥٠٠٬٠٠٠ | ٥٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٧ % | Adage Capital Management, L.P. | ٤٠٠٬٠٠٠ | ٤٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٥ % | BlackRock Institutional Trust Company, N.A. | ٣٨٠٬١٨٧ | ٣٧٥٬٩٧٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧ % | Marshall Wace LLP | ٣١٨٬٤٤٠ | ٣١٨٬٤٤٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٧ % | Valliant (John Fitzmaurice) | ٣١٨٬١٤٧ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٣٧ % | Fred Alger Management, LLC | ٣١١٬٩٧٤ | ٣١١٬٩٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥ % | Jennison Associates LLC | ٣٠١٬٠٢٠ | ٣٠١٬٠٢٠ | ٣١/١٢/٢٠٢٣ |
٠٫٣٥ % | Point72 Asset Management, L.P. | ٢٩٣٬٦١١ | -٣٥٬٢٥٧ | ٣١/١٢/٢٠٢٣ |
٠٫٣٣ % | Pier Capital, LLC | ٢٧٧٬١١١ | ٢٧٧٬١١١ | ٣١/١٢/٢٠٢٣ |
٠٫٣٠ % | Walleye Capital LLC | ٢٥١٬٢١٣ | ٢٥١٬٢١٣ | ٣١/١٢/٢٠٢٣ |
٠٫٢٩ % | Sio Capital Management, LLC | ٢٤٦٬٠٣٦ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | UBS Financial Services, Inc. | ٢٢٣٬٠٩٢ | ١٢٩٬٧٨٣ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | Woodline Partners LP | ٢٢٢٬٤٦٢ | ١٤٤٬٤٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫٢٥ % | UBS O'Connor LLC | ٢١٣٬١٠٧ | -٦١٬٤٦١ | ٣١/١٢/٢٠٢٣ |
٠٫١٨ % | Schonfeld Strategic Advisors LLC | ١٥٣٬٧٩٢ | ١٥٣٬٧٩٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٧ % | Morgan Stanley Smith Barney LLC | ١٤٦٬٣٢٨ | -١٩٬٧٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٧ % | Privium Fund Management BV | ١٤١٬٧٥٠ | ١٤١٬٧٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٦ % | Boothbay Fund Management, LLC | ١٣٣٬٥٥٠ | ١٣٣٬٥٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Two Sigma Investments, LP | ١٣٠٬٤٣٣ | ٩٨٬٣٣٣ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Atika Capital Management LLC | ١٣٠٬٤٠٠ | ١٣٠٬٤٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Sofinnova Investments, Inc | ١٢٥٬٢٩٩ | ٨٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Healthinvest Partners AB | ١٢٥٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٣ % | Verition Fund Management LLC | ١٠٩٬٣٨٦ | ١٠٩٬٣٨٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Franklin Advisers, Inc. | ٨٩٬١٠٠ | ٨٩٬١٠٠ | ٣١/١/٢٠٢٤ |
٠٫١٠ % | Invesco Advisers, Inc. | ٨٨٬١٣٠ | ٢٥٬٤٥١ | ٢٩/٢/٢٠٢٤ |
٠٫١٠ % | Jump Financial, LLC | ٨٦٬١٩٩ | ٨٦٬١٩٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩ % | Yarbrough Capital, LLC | ٧٦٬٨٧٢ | 0 | ٣١/٣/٢٠٢٤ |
٠٫٠٨ % | Cubist Systematic Strategies, LLC | ٦٧٬٤٧٠ | ٦٧٬٤٦٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Morgan Stanley & Co. LLC | ٦٠٬٢٥٣ | ٦٠٬٢٥٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | BlackRock Investment Management, LLC | ٥٩٬١٥٤ | -٢٬٢٦٣ | ٢٩/٢/٢٠٢٤ |
٠٫٠٧ % | Sectoral Asset Management Inc. | ٥٧٬٢٩٧ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Gannon (Steven R) | ٥٦٬٤٠٠ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٠٧ % | abrdn Investments Limited | ٥٦٬١٠٠ | ٥٦٬١٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠٦ % | Citadel Advisors LLC | ٥٤٬١٢٣ | ٥٤٬١٢٣ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦ % | Chartwell Investment Partners, LLC | ٤٩٬٨٩٠ | ٤٩٬٨٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦ % | Avantis Investors | ٤٨٬٥٢٦ | ٤٨٬٥٢٦ | ٣١/٣/٢٠٢٤ |
٠٫٠٦ % | Assenagon Asset Management S.A. | ٤٨٬١٣٨ | ٣٬٥٣٦ | ٢٩/٢/٢٠٢٤ |
٠٫٠٥ % | Superstring Capital Management LP | ٤٥٬٨٠١ | ٤٥٬٨٠١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥ % | Medical Strategy GmbH | ٤٤٬٠٠٠ | ٤٤٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥ % | Tekla Capital Management LLC_NLE | ٤٣٬٣٩٤ | 0 | ٣٠/٦/٢٠٢٣ |
٠٫٠٥ % | Khuong (Chau Quang) | ٤٢٬٠٩٣ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٠٥ % | Geode Capital Management, L.L.C. | ٣٩٬٣٤٦ | ٨٬٤٧٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٥ % | Burak (Eric) | ٣٨٬٤٩٠ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٠٥ % | BlackRock Advisors (UK) Limited | ٣٨٬٣٩١ | ١٬٨٤٣ | ٣١/٣/٢٠٢٤ |
٠٫٠٤ % | BlackRock Asset Management Ireland Limited | ٣٥٬٥٧٨ | ٣٥٬٥٧٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤ % | Raymond James Financial Services Advisors, Inc. | ٣١٬١٤٥ | ٣١٬١٤٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤ % | NEOS Investment Management, LLC | ٣٠٬٩٣٩ | ١٣٬٤٤٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٤ % | RBC Capital Markets Wealth Management | ٣٠٬٦٦٩ | ٣٠٬٦٦٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣ % | Jane Street Capital, L.L.C. | ٢٨٬١٣٢ | ٢٨٬١٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣ % | Driehaus Capital Management, LLC | ٢٣٬٢٧٠ | 0 | ٢٩/٢/٢٠٢٤ |
٠٫٠٣ % | XTX Markets LLC | ٢٣٬١٦١ | ٢٣٬١٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣ % | The Vanguard Group, Inc. | ٢٣٬٠٢٩ | ٢٣٬٠٢٩ | ٣١/٣/٢٠٢٤ |
٠٫٠٣ % | Credit Suisse Funds AG | ٢١٬٨٦٧ | ٢١٬٨٦٧ | ٢٩/٢/٢٠٢٤ |
٠٫٠٣ % | abrdn Inc. | ٢١٬٦٩٧ | ٢١٬٦٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٣ % | Goldman Sachs Asset Management, L.P. | ٢١٬٦٠٥ | -١٧٠ | ٣١/٣/٢٠٢٤ |
٠٫٠٢ % | T. Rowe Price Associates, Inc. | ٢١٬١٠٠ | ٢١٬١٠٠ | ٢٩/٢/٢٠٢٤ |
٠٫٠٢ % | Raymond James & Associates, Inc. | ٢٠٬٢٠٠ | ٢٠٬٢٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Federated Hermes Equity Management Company of Pennsylvania | ٢٠٬٠٠٠ | -٨٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Group One Trading, L.P. | ١٩٬١٣٤ | ١٩٬١٣٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Susquehanna International Group, LLP | ١٨٬٤٦٥ | ١٨٬٤٦٥ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | ProShare Advisors LLC | ١٧٬٦٢٣ | ١٢٬٢١٣ | ٣١/٣/٢٠٢٤ |
٠٫٠٢ % | Forefront Analytics, LLC | ١٦٬٧١٥ | -١٦٬٩٧٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Belvedere Trading, LLC | ١٦٬٣٤٩ | ١٦٬٣٤٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Alpine Associates Management Inc. | ١٥٬٧٠٠ | ١٥٬٧٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠٢ % | Goldman Sachs & Company, Inc. | ١٥٬١٣٢ | ١٥٬١٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٢ % | Rawat (Mohit) | ١٢٬٨٤٣ | ١٢٬٨٤٣ | ٣١/٨/٢٠٢٣ |
٠٫٠١ % | Squarepoint Capital LLP | ١٢٬٧٥٧ | ١٢٬٧٥٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠١ % | Simplex Trading, LLC | ١٢٬٥٠١ | ١٢٬٤٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠١ % | Leamon (Christopher Paul Ph.D.) | ١١٬٩٥٧ | ١١٬٩٥٧ | ٣١/٨/٢٠٢٣ |
٠٫٠١ % | Envestnet Asset Management, Inc. | ١١٬٤٥٤ | ١١٬٤٥٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠١ % | Crowley (John Joseph CPA) | ١٠٬٤١٠ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٠١ % | Vanguard Investments Australia Ltd. | ١٠٬٣٨٠ | ١٠٬٣٨٠ | ٢٩/٢/٢٠٢٤ |
٠٫٠١ % | Renaissance Technologies LLC | ١٠٬٠٠٠ | ١٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠١ % | AlphaSimplex Group, LLC | ٩٬٥٩٠ | ٩٬٥٩٠ | ٢٩/٢/٢٠٢٤ |
٠٫٠١ % | Preston (Heather Elizabeth) | ٨٬٨٢٣ | 0 | ١٧/٢/٢٠٢٣ |
٠٫٠١ % | Cutler Group, LP | ٨٬٦٠٠ | ٧٬٥٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠١ % | Mercer Global Investments Management Ltd | ٨٬٦٠٠ | ٨٬٦٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠١ % | State Street Global Advisors Ireland Limited | ٨٬٥٠٠ | ٨٬٥٠٠ | ٣١/٣/٢٠٢٤ |
٠٫٠١ % | American Century Investment Management, Inc. | ٨٬٣٩٩ | ٨٬٣٩٩ | ٣١/٣/٢٠٢٤ |
٠٫٠١ % | China Universal Asset Management Co., Ltd. | ٨٬٣٧٦ | ٨٬٣٧٦ | ٣١/١٢/٢٠٢٣ |